Interoperability and Standards: The Way for Innovative Design in Networked Working Environments

Organised by: Cranfield UniversityIn today’s networked economy, strategic business partnerships and outsourcing has become the dominant paradigm where companies focus on core competencies and skills, as creative design, manufacturing, or selling. However, achieving seamless interoperability is an ongoing challenge these networks are facing, due to their distributed and heterogeneous nature. Part of the solution relies on adoption of standards for design and product data representation, but for sectors predominantly characterized by SMEs, such as the furniture sector, implementations need to be tailored to reduce costs. This paper recommends a set of best practices for the fast adoption of the ISO funStep standard modules and presents a framework that enables the usage of visualization data as a way to reduce costs in manufacturing and electronic catalogue design.Mori Seiki – The Machine Tool Compan

Coordinating negotiations in data-intensive collaborative working environments using an agent-based model-driven platform

This paper tackles the interoperability problems of enterprise information systems by presenting a distributive model-driven platform for parallel coordination of multiple negotiations in data-intensive collaborative working environments. The proposed model was validated and verified by an industrial application scenario within the European research project H2020 C2NET (Cloud Collaborative Manufacturing Networks). This real scenario developed data-intensive collaborative and cloud-enabled tools that allow the optimisation of the supply network of manufacturing SMEs, proposing a negotiation solution based on a model-driven interoperable decentralised architecture.info:eu-repo/semantics/acceptedVersio

Instability of scalar perturbation in a phantomic cosmological scenario

Scalar perturbations can grow during a phantomic cosmological phase as the big rip is approached, in spite of the high accelerated expansion regime, if the equation of state is such that $\frac{p}{\rho} = \alpha < - {5/3}$. It is shown that such result is independent of the spatial curvature. The perturbed equations are exactly solved for any value of the curvature parameter $k$ and of the equation of state parameter $\alpha$. Growing modes are found asymptotically under the condition $\alpha < - {5/3}$. Since the Hubble radius decreases in a phantom universe, such result indicates that a phantom scenario may not survive longtime due to gravitational instability.Comment: Latex file, 6 page

Organometallic Complex Strongly Impairs Chikungunya Virus Entry to the Host Cells

Chikungunya fever is a disease caused by the Chikungunya virus (CHIKV) that is transmitted by the bite of the female of Aedes sp. mosquito. The symptoms include fever, muscle aches, skin rash, and severe joint pains. The disease may develop into a chronic condition and joint pain for months or years. Currently, there is no effective antiviral treatment against CHIKV infection. Treatments based on natural compounds have been widely studied, as many drugs were produced by using natural molecules and their derivatives. Alpha-phellandrene (α-Phe) is a naturally occurring organic compound that is a ligand for ruthenium, forming the organometallic complex [Ru2Cl4(p-cymene)2] (RcP). Organometallic complexes have shown promising as candidate molecules to a new generation of compounds that presented relevant biological properties, however, there is a lack of knowledge concerning the anti-CHIKV activity of these complexes. The present work evaluated the effects of the RcP and its precursors, the hydrate ruthenium(III) chloride salt (RuCl3⋅xH2O) (Ru) and α-Phe, on CHIKV infection in vitro. To this, BHK-21 cells were infected with CHIKV-nanoluciferase (CHIKV-nanoluc), a viral construct harboring the nanoluciferase reporter gene, at the presence or absence of the compounds for 16 h. Cytotoxicity and impact on infectivity were analyzed. The results demonstrated that RcP exhibited a strong therapeutic potential judged by the selective index > 40. Antiviral effects of RcP on different stages of the CHIKV replicative cycle were investigated; the results showed that it affected early stages of virus infection reducing virus replication by 77% at non-cytotoxic concentrations. Further assays demonstrated the virucidal activity of the compound that completely blocked virus infectivity. In silico molecular docking calculations suggested different binding interactions between aromatic rings of RcP and the loop of amino acids of the E2 envelope CHIKV glycoprotein mainly through hydrophobic interactions. Additionally, infrared spectroscopy spectral analysis indicated interactions of RcP with CHIKV glycoproteins. These data suggest that RcP may act on CHIKV particles, disrupting virus entry to the host cells. Therefore, RcP may represent a strong candidate for the development of anti-CHIKV drugs

A large outbreak of Legionnaires’ Disease in an industrial town in Portugal

Background We describe the investigation and control of an outbreak of Legionnaires’ disease in Portugal in October, November and December 2014. Methods Confirmed cases were individuals with pneumonia, laboratory evidence of Legionella pneumophila serogroup 1 and exposure, by residence, occupational or leisure to the affected municipalities. 49 possible sources were reduced to four potential sources, all industries with wet cooling system, following risk assessment. We geo-referenced cases’ residences and the location of cooling towers defining four study areas 10 km buffer centered on each cooling tower system. We compared the number of cases with expected numbers, calculated from the outbreak's attack rates applied to 2011 census population. Using Stones’ Test, we tested observed to expected ratios for decline in risk, with distance up to 10 km four directions. Isolates of Legionella pneumophila were compared using molecular methods. Results We identified 403 cases, 377 of which were confirmed, 14 patients died. Patients became ill between 14 October and 2 December. A NE wind and thermal inversion were recorded during the estimated period of exposure. Disease risk was highest in people living south west from all of the industries identified and decreased with distance (p < 0.001). 71 clinical isolates demonstrated an identical SBT profile to an isolate from a cooling tower. Whole genome sequencing identified an unusual L. pneumophila subsp. fraseri serogroup 1 as the outbreak causative strain, and confirmed isolates’ relatedness. Conclusions Industrial wet cooling systems, bacteria with enhanced survival characteristics and a combination of climatic conditions contributed to the second largest outbreak of Legionnaires’ disease recorded internationally.info:eu-repo/semantics/publishedVersio

Erratum to: The study of cardiovascular risk in adolescents – ERICA: rationale, design and sample characteristics of a national survey examining cardiovascular risk factor profile in Brazilian adolescents

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